| Datum |
Beginn |
Spiel |
| 14.08.2021 (Sa) |
20:00 |
Fortuna Sittard – FC Twente |
| 22.08.2021 (So) |
12:15 |
FC Twente – Ajax Amsterdam |
| 28.08.2021 (Sa) |
18:45 |
SC Cambuur – FC Twente |
| 11.09.2021 (Sa) |
16:30 |
FC twente – FC Utrecht |
| 19.09.2021 (So) |
14:30 |
Vitesse Arnheim – FC Twente |
| 23.09.2021 (Do) |
21:00 |
FC Twente – AZ Alkmaar |
| 26.09.2021 (So) |
14:30 |
sc Heerenveen – FC Twente |
| 01.10.2021 (Fr) |
20:00 |
FC Groningen – FC Twente |
| 17.10.2021 (So) |
16:45 |
FC Twente – Willem II |
23.10.2021 (Sa) |
20:00 |
FC Twente – NEC (verschoben) |
| 24.10.2021 (So) |
12:15 |
FC Twente – NEC (neuer Termin) |
30.10.2021 (Sa) |
21:00 |
PSV – FC Twente (verschoben) |
| 30.10.2021 (Sa) |
16:30 |
PSV – FC Twente (neuer Termin) |
| 05.11.2021 (Fr) |
20:00 |
FC Twente – Heracles Almelo |
| 20.11.2021 (Sa) |
18:45 |
Sparta Rotterdam – FC Twente |
| 28.11.2021 (So) |
14:30 |
FC Twente – Feyenoord |
| 05.12.2021 (So) |
14:30 |
Go Ahead Eagles – FC Twente |
11.12.2021 (Sa) |
18:45 |
FC Twente – Waalwijk (verschoben) |
| 12.12.2021 (So) |
12:15 |
FC Twente – Waalwijk (neuer Termin) |
| 18.12.2021 (Sa) |
21:00 |
PEC Zwolle – FC Twente |
| 22.12.2021 (Mi) |
21:00 |
FC Utrecht – FC Twente |
| 15.01.2022 (Sa) |
20:00 |
FC Twente – sc Heerenveen |
| 22.01.2022 (Sa) |
21:00 |
Willem II – FC Twente |
| 05.02.2022 (Sa) |
21:00 |
FC Twente – Vitesse Arnheim |
