Spielplan der neuen Saison 2017 – 2018
| Nr. | Datum | Spiel | Beginn |
| 1 | 13.08.2017 (So) | Feyenoord – FC Twente | 14:30 |
| 2 | 19.08.2017 (Sa) | FC Twente – VVV Venlo | 18:30 |
| 3 | 26.08.2017 (Sa) | PEC Zwolle – FC Twente | 19:45 |
| 4 | 10.09.2017 (So) | Sparta Rotterdam – FC Twente | 14:30 |
| 5 | 17.09.2017 (So) | FC Twente – FC Utrecht* | 14:30 |
| 6 | 24.09.2017 (So) | FC Groningen – FC Twente | 14:30 |
| 7 | 29.09.2017 (Fr) | FC Twente – Heracles Almelo | 20:00 |
| 8 | 15.10.2017 (So) | Willem II – FC Twente | 14:30 |
| 9 | 21.10.2017 (Sa) | FC Twente – Roda JC | 20:45 |
| 10 | 27.10.2017 (Fr) | FC Twente – Excelsior | 20:00 |
| 11 | 05.11.2017 (So) | PSV – FC Twente | 16:45 |
| 12 | 18.11.2017 (Sa) | FC Twente – sc Heerenveen | 18:30 |
| 13 | 24.11.2017 (Fr) | AZ – FC Twente | 20:00 |
| 14 | 02.12.2017 (Sa) | FC Twente – Ajax | 18:30 |
| 15 | 09.12.2017 (Sa) | FC Twente – ADO Den Haag | 20:45 |
| 16 | 12.12.2017 (Di) | NAC Breda – FC Twente | 18:30 |
| 17 | 16.12.2017 (Sa) | FC Twente – Vitesse | 20:45 |
| 18 | 23.12.2017 (Sa) | Excelsior – FC Twente | 20:45 |
| Winterstop | |||
| Nr. | Datum | Spiel | Beginn |
| 19 | 20.01.2018 (Sa) | Roda JC – FC Twente | 18:30 |
| 20 | 27.01.2018 (Sa) | FC Twente – PSV | 19:45 |
| 21 | 03.02.2018 (Sa) | sc Heerenveen – FC Twente | 18:30 |
| 22 | 06.02.2018 (Di) | FC Twente – AZ | 18:30 |
| 23 | 11.02.2018 (So) | Ajax – FC Twente | 12:30 |
| 24 | 18.02.2018 (So) | FC Twente – Sparta Rotterdam | 14:30 |
| 25 | 25.02.2018 (So) | FC Utrecht – FC Twente | 16:45 |
| 26 | 04.03.2018 (So) | FC Twente – FC Groningen | 16:45 |
| 27 | 09.03.2018 (Fr) | Heracles Almelo – FC Twente | 20:00 |
| 28 | 17.03.2018 (Sa) | FC Twente – Willem II | 18:30 |
| 29 | 01.04.2018 (So) | VVV Venlo – FC Twente | 12:30 |
| 30 | 08.04.2018 (So) | FC Twente – Feyenoord | 14:30 |
| 31 | 14.04.2018 (Sa) | ADO Den Haag – FC Twente | 18:30 |
| 32 | 17.04.2018 (Di) | FC Twente – PEC Zwolle | 18:30 |
| 33 | 29.04.2018 (So) | Vitesse – FC Twente | 14:30 |
| 34 | 06.05.2018 (So) | FC Twente – NAC Breda | 14:30 |